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GHRHs (like Tesamorelin and Mod GRF 1-29) work by stimulating the production and release of natural growth hormone lines, while GHRPs (like Ipamorelin) amplify that signal and suppress somatostatinthe hormone responsible for halting growth hormone release

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GLP-1 depletes B12 by (1) reduced food intake and (2) slowed gastric absorption

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